According to ESRB, this game contains: Violence, Blood, Strong Language, Sexual Themes
Parents should be careful about this game-it seems harmless at first glance (especially when looking at the cover art), but actually contains references to alcoholism, sex, and homosexuality, as well as a whole lot of beheadings. Peculiarly, most of the questionable material could have been easily removed, leaving a T-rated game. Apparently someone thought an M was more marketable.
RPG fans might be interested to discover just how the Fable team has played with and altered the genre conventions. Interested, but probably not pleased. It's worth a look, but probably not a purchase.
Zelda Fans who can't wait for the next installment might want to consider purchasing it once it's cheap, as it will provide a passable substitute, and little more.
Deaf and Hard of Hearing gamers will have problems with the game. While all the main plot text is subtitled, the incidental villager text is not, making the social interaction very, very difficult. Of course, it's not an important or interesting part of the game, so it will still be playable.