According to ESRB, this game contains: Blood, Mild Language, Suggestive Themes, Mild Violence
Parents might be put off by the Teen rating, but honestly, there's not much to get offended over in this title. There's one scantily-clad female character (who's barely in the game) and most of the cursing is censored out anyway.
Fans of the anime would probably have more fun just watching the show. From what I understand this title doesn't follow the anime's plotline in any significant way, making it more of a sidestory. This would be cool if the game were good, but the only reason to really play the game is if you're a huge fan of Ed and Al—and even then, there aren't enough anime cutscenes and voiced dialogue to really make it worthwhile.
Casual gamers will most likely love this title at first, but soon realize that it's shown all its tricks in the first area and that the rest of the game is simply more of the same. This might be okay if the game is played in small doses, but most gamers will get bored of the repetitive gameplay long before the end credits.
Deaf and Hard of Hearing gamers will be disappointed. While most of the game features plain text, the major story scenes--which are done in animation—feature no subtitles, meaning that anyone who can't hear the action will be missing out on huge parts of the game's plot.