What a game, what a game.
You play as a plague-stricken protagonist washed up on a tropical island (not pictured). The island is an outpost researching a cure for the plague, but it is being stalked by a terrible beast. You have to survive, find a cure and escape with it.
You're as weak as a baby at the start of the game, and any major exertion such as swimming will result in an onslaught of fever. You need to map the island, research the cure, and synthesise it from the local fauna. Over time, you get stronger as you discover recipies for various drugs, but the beast also takes a keener interest in you as time goes on.
I can't recommend it straight up as it is so different, but if you see it in a sale give it a whirl. It's an incredible game for atmosphere and the sheer horror of being completely lost, feverish and no idea where there's a safe haven can't be overstated. It would have been in my Top 5 last year if I'd played it, no doubt.