According to ESRB, this game contains: Comic Mischief, Mild Language, Mild Violence, Suggestive Themes
Parents might be upset by the weirdness in the game, and how downright creepy some of Muto's morphs can be. Younger kids might get upset by some of the imagery.
Deaf and Hard of Hearing won't have any difficulty playing, as there is plenty of text to help guide players. The voice acting, while of a decent quality and over the top, gets annoying quite quickly. Not much will be missed in the audio department.
Platform fans might want to give a pass on this game and take a look at Ratchet & Clank or Sly Cooper instead. While the premise of Dr. Muto is quite interesting, it never materializes into an effective gameplay experience.